Paul's Heart

Life As A Dad, And A Survivor

Archive for the category “Side Effects”

Understanding Drug Interactions


I got an unusual phone call the other day.  It was from my pharmacist.  She wanted to make me aware of two medicines that I was having renewed, they could cause a potential problem.

Unfortunately, while typically I write about my experiences based on the world of cancer, there are literally millions of people, either currently or in the past, having dealt with Covid19, need to be aware of the medicines and potential interactions.

Up until around 2008, all I had really taken was a prescription for my thyroid, damaged from my radiation therapy for Hodgkin’s Lymphoma, something for my high cholesterol, and to help with my blood pressure.  In 2008, that all changed.  To date, I now take nine different medications, all related to the late effect issues that I deal with.  In twelve years, this is the first time I had heard from a pharmacist personally though.

I have a large number of doctors that I deal with, and I trust them with the medicines I need to take.  I trust them to be aware of any interactions between the medications, and to weigh the benefits and risks.

In 2019, I had to have yet another procedure, the second on my heart.  But unlike the open heart surgery I had in 2008, this procedure was going to involve a stent (ironically for an artery that they knew about in 2008 with the other surgery, just did not fix it).  Because of the stent, I would need to take more than the baby aspirin I took from my open heart surgery.  I was prescribed an actual blood thinner.

Later in the year, I saw a different cardiologist, who noted on my record, the list of medications that I took, and noticed a medicine I take for gastrointestinal issues.  He was concerned.  As he stated, there is a likelihood that that medicine and the blood thinner interaction could actually negate the benefit of the blood thinner.  I would need to change the medicine I took for my stomach.

There was only one problem with that.  No other medicines are able to handle the issue I deal with for my stomach.  We are talking quality of life at this point.  Not to mention the fact, not being able to take this medicine would also increase risks of complications with my GI system, and likely lead to aspiration pneumonia (I have written other posts on this).

Then the suggestion, was to try a newer blood thinner.  The problem with that, the cost was enormous and unaffordable.

As a consensus made among all of my doctors, 95% of us, including me, agreed that I would continue on the path that I had been for the last year.  And that was the last I had heard of it, until the phone call from the pharmacist.

I want to be clear.  I completely am so appreciative for a pharmacist who does so much more than just fills prescriptions.  This is the first time in my life, I have ever had a pharmacist even tell me of a potential conflict.  Up until then, if you wanted to find out about conflicts, you went to the web site drugs.com for the potential issues.

Now, with Covid19, and the treatments for it, things get really complicated for me, but not necessarily a cakewalk for someone who has never had cancer.  You still need to have that awareness.

One of the early popular drugs thought to be helpful, now disproven, when combined with an antibiotic, could cause cardiac issues.  The use of steroids?  Not when you have a known heart condition.  Treating someone like me who has a history of a drug called Bleomycin (for my chemo) with oxygen, a huge no-no.  I have spent decades being aware of the medicines I need to stay alive, or save it.  Even foods you eat can impact a medicine you need such as grapefruit.  Certain statin drugs (for cholesterol) actually have their effects reduced by grapefruit.  If you take a medicine for your thyroid, they tell you not to take any other medicines with it, because the drug will affect the absorption of any other medications.  I have learned way more than I have ever wanted to about medicine and prescriptions.

It would be just so much easier not to have to take any of them.

Vaccine Opinion From Someone Who Has A Reason To Get One, But Might Not


As a long term survivor of cancer, Hodgkin’s Lymphoma, who deals with a lot of issues related to late developing side effects from my treatments, as well as a key issue of immunocompromise status, there could be no more important news to me currently than the approval of a vaccine for Covid19.  Of all my co-morbidities (issues that complicate my health if I get Covid19), my heart, my lungs, being diabetic, the one thing that will stand out above all others because it is what leaves me more susceptible in the first place to contracting Covid19, not having a spleen, or being asplenic.

At one time, it was believed that people could do without their spleen, an organ that basically filters the blood, but now believed to be quite important when it comes to fighting infections.

Back in 1988, when my spleen was removed as part of a staging procedure (to see how bad my cancer was), I had to take certain vaccines to boost my immunity.  These were not lifetime like the ones we got in school, measles/mumps/rubella and others.  One vaccine was for the flu, another pneumonia, and the other meningitis.  I was told, the flu would need to be done every year, but the other two would be good for life.  Spoiler alert, not true.  I won’t get into that here, but I have gotten multiple boosters of both, since not having a spleen, I cannot build up immunity against those two issues.

I want to state very clearly, I am not an anti-vaxxer.  I also do not buy into any conspiracies about vaccines.  And I object to vaccines being made political.  Decisions I have made about getting vaccinated for anything have been personal, and made pending on status of mandatory or necessary, medically, or legally.

But in my lifetime, Covid19 is the most lethal contagion I have ever witnessed.  And I used to work in medical research, so that says a lot.  With all my co-morbidities, and access to the doctors that know my medical history, I am someone who should get a vaccine for Covid19… when it is not only available, but safe.

Having worked in medical research, I know the process takes time, a long time.  Having been cured of one of the most fatal illnesses, cancer, I know all too well about treatments and therapies that are not studied at length enough to be aware of all the risks.

Here is what I do know.  I know that scientists were able to build on the knowledge that they already previously had on other Corona viruses and SARS viruses of the past.  That would be the starting block for the vaccine for Covid19.  Then it should be just a matter of the scientists doing their job, that they are good at, and finding something that will work, as safely as possible.  Then there is the testing, eventually testing on humans in three stages.  Besides the actual research, this is a step that takes time, and a lot of volunteers.  And then there is the bureaucratic process of approval.

If you think that is a long paragraph, then you have to know, vaccine development is a long process.  In the world, we are recognized as the leader in vaccine development, especially when it comes to safety.  That is how science works.

Have you ever heard of the expression, “putting your thumb on a scale”, or perhaps, even been a practical joker like me, sneaking up behind someone standing on a scale to weigh themselves, and then stealthily sneaking the tip of my foot onto the scale to make the weight a little heavier?

In 2020, that is unfortunately what has happened, intentional or not, to impact the develop a vaccine for Covid19.  Under extreme pressure from a horrifying strategic decision on how to handle the Coronavirus pandemic, the President instead was forced to get to the solution much quicker than time would allow.  The result is like trying to use water to put out a fire fueled by gasoline.

In all honestly, from all things considered, early knowledge of Corona and SARS viruses, the best scientists in the world, the top vaccines currently up for consideration might just be what we need to finally get a grip on this pandemic.  But for a majority of the country, who rely on facts and science to make their decisions, find it much harder to make the decision to get this vaccine, because a “thumb was placed on a scale” of time, to make the process go faster, likely for a combination of political gain as well as humanity.

As I write this, the FDA is holding a meeting to decide on emergency use authorization.  If approved, it is potentially a big deal to the possible end of the pandemic.  Prioritization of vaccines has already been recognized.  Once approved, the vaccines will get shipped out, and into the arms.

But not so fast.  Like I said, there is a three-step process of human trials taking many months to study for side effects.  These trials are tested on healthy, non-compromised subjects.  What does that mean?  That means that the person has no issues that might skew the results.  Someone, like me.  I have all the co-morbidities that make Covid19 lethal to me.  I would not have been approved for that study, even if I had paid to do it.

We are told, the vaccine from Pfizer will have a 95% success.  As many vaccines have, there could be side effects that make it somewhat unpleasant for up to a day.  But the tradeoff, immunity to Covid19, and the lingering effects the virus causes, makes that temporary feeling worth it.

Here is the problem.  There is not data yet released, meaning, it likely has not even been studied, on certain groups of patients.  For instance, there is no data on:

  • pregnant and nursing mothers
  • children under 16
  • people with compromised immune systems (like me)
  • those with a history of reactions or allergies to vaccines

Look at those four groups.  That is a serious segment of our population who will have a difficult decision to make, weighing the risk or benefit of getting the vaccine or not.

And that is not the only factor to consider.  As a thirty year survivor of Hodgkin’s Lymphoma, I deal with late side effects from the treatments used to treat me, side effects that medicine was unaware of at the time.  Cancer patients were not expected to live longer than five years, according to statistics, so we were not studied.

Rushing the process of the vaccine, while good for stopping the spread of the pandemic, does not allow for science to study the potential risks, short or long term.  Even now, science is talking about not knowing the late effects of contracting the virus, because they do not know.

Look, there is a reason we have not seen Polio in decades.  A process worked.  I am too young to recall what it was like to watch someone with Polio, but my mother is old enough to remember, and she said it was horrific.  I am hoping in my lifetime I never see another virus outbreak like this, and definitely not handled the way that this has been handled.

I am not letting the media or any politician tell me what to do.  I am in contact with my doctors (science) who will recommend if I should get the vaccine or not.  For now, a combination of the unknown data, my doctors have recommended a “wait and see” approach of one to two months before consideration.  This is a difficult spot, because, being vulnerable, I am one who needs the vaccine.

The main thing that can do the most damage, is misinformation.  Stop reading it.  Stop sharing it.  Get your information from your doctor for your specific situation if you should get the vaccine or not.  You will be the one to decide if you are one of the lucky ones to ride it out without the vaccine and having exposure, or one of the 300,000 Americans who have died from it.

 

Tammy


One of the posts I never wanted to write about.  I actually don’t want any opportunities to write memorials of fellow cancer survivors.  When one passes, it is a stark reminder, that in spite of beating our cancer, issues that may have developed from our treatments, we are still vulnerable.  Our fight is not over.

I barely had my first computer when I first came across Tammy.  In fact, I recall using “dial up” with a 56k modem and an “aol” address.  We were both on a list serve (an old style email list) for people who had battled Hodgkin’s Lymphoma.  We were both around the same age.  Treated around the same time, approximate two years before me, though different cancer networks in different states.  In spite of the similarities, she was treated with a much stronger attack of treatment than me.

I was barely five years passed remission.  Tammy spent a lot of time, encouraging me to keep vigilant on follow-ups, all the while, occasionally filling me on some serious issues that she dealt with, related to her treatments.  I could not understand, why she was dealing with these severe issues, and I seemingly had none.

Her list of health issues caused by her treatments is way longer than I could write or even comprehend.  I would eventually develop some of the many issues that she experienced.  And if you have followed my blog, my list is only 10% of the size of Tammy’s issues.  And the number of critical events that she experienced defied comprehension that we would have a friendship decades long.  But she just kept going.  The energizer bunny had nothing on her.

Regardless of how many issues she faces, or how often, life for her continued on.  So proud of her children, I saw them all grow, and much to her surprise, witnessed her becoming a grandmother, several times.  Always an inspiration to me with what she had been through, the one comment that she said to me that always has stuck in my head, as an order to never stop fighting, “I never thought I would see being a grandmother.  And look at how I have been blessed.”  I will never forget those words.

My oldest daughter’s name is Madison.  Upon finding out that she was having a granddaughter, was also going to be named Maddison (just a coincidence), seeing all the photos of “my” Madison in cute baby clothes gave her a rush of excitement to once again shop for baby girl clothing, something she had not experienced since the birth of her daughter.

Tammy, like many of my fellow survivors, was 100% selfless.  No matter how awful she felt, even in her weakest moments, when she had the strength to respond, she took those moments.

We lived in different states, but still made arrangements for families to get together, including gatherings of other Hodgkin’s survivors.  I just posted this photo the other day:

We were not just fellow survivors.  Our lives were not just about cancer and survivorship.  She was one of the first to show me there was still so much to be thankful for, so much to strive for, and so much to live for.  But I will be forever grateful for learning to face the health issues with a resolve not to accept anything less than the best care, and to not settle for medical personnel having no idea what to do with us.

I won’t lie.  I never allowed myself to feel sorry for myself, or to feel I want to give up, because of Tammy.  Everything she had gone through, I had no right to ever say, “I’ve had enough.”  And now, the one I looked to, to keep me going forward, is gone.  Don’t get me wrong, I have so many reasons to keep going on myself.  But I always believed, as long as Tammy was still here, I was still going to be here.  If anyone was proving immortality, against all odds, it was Tammy.

Tammy, I am selfish.  I wish you had more time down here.  But I know it was hard.  And now you get to spend some time with your other grandson, to spend a belated birthday.  I will never forget you and what you did for me, to get me through some of the toughest moments I faced in my life.  You are going to be so missed, not just by me, but those wonderful children I got to witness grow, and all the beautiful grandchildren you were blessed to spend time with.  There is also a large community of survivors who also knew you and what you had gone through.  It does not hurt any less, the only consolation being, you are no longer in that pain.

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